DIS3 Rabbit Polyclonal Antibody
CAT#: TA368185
DIS3 rabbit polyclonal antibody
Size: 25 ul
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CNY 1,999.00
CNY 3,280.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm or Nucleus |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide of human DIS3 |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C. |
Gene Name | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease |
Database Link | |
Background | The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3' to 5' exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3' regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events. |
Synonyms | 2810028N01Rik; bA555G22.1; dis3p; DKFZp667L1817; EXOSC11; FLJ10484; KIAA1008; MGC33035; RP11-342J4.3; RRP44 |
Reference Data |
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