Rb2 p130 (RBL2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Lncap cell IHC: 30-150 Positive control: Human lung cancer Predicted cell location: Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human RBL2
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	128 kDa
Gene Name	RB transcriptional corepressor like 2
Database Link	Entrez Gene 5934 Human UniProt ID Q08999
Background	Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation.
Synonyms	FLJ26459; p130; PRB2; Rb2; RBR-2
Reference Data

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