CLASP2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human CLASP2
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Gene Name	cytoplasmic linker associated protein 2
Database Link	Entrez Gene 23122 Human UniProt ID O75122
Background	CLASP2 (cytoplasmic linker associated protein 2), also known as KIAA0627 or hOrbit2, is a 1,294 amino acid protein that contains five HEAT repeats and localizes to the cytoplasm and the cytoskeleton, as well as to the kinetochore and the golgi apparatus. Expressed primarily in brain tissue, CLASP2 functions as a microtubule plus-end tracking protein that regulates the stability of dynamic microtubules and is required for the proper polarization of cytoplasmic microtubule arrays in migrating cells. CLASP2 interacts with EB1, EB3, ELKS and CLIP-115 and, in addition to stabilizing microtubules, plays an important role in maintaining the stability of the kinetochore and is crucial for proper chromosomal alignment. CLASP2 is subject to phosphorylation by GSK-3β, an event that is thought to negatively regulate the ability of CLASP2 to bind to microtubules. Two isoforms of CLASP2, designated beta and gamma, exist due to alternative splicing events.
Synonyms	hOrbit2; KIAA0627
Reference Data

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