Hamp Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	This antibody has been tested and validated in ELISA against Hepcidin- 25. Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide H-Asp-Thr-Asn-Phe-Pro-Ile-Cys-Leu-Phe-Cys-Cys- Lys-Cys-Cys-Lys-Asn-Ser-Ser-Cys-Gly-Leu-Cys-Cys-Ile-Thr-OH coupled to carrier protein.
Formulation	Protein A affinity purified from antiserum, lyophilized, packaged under nitrogen. Reconstitute by adding 0.2ml distilled water. This stock solution contains 2mg/ml IgG, phosphate buffer saline pH 7.4 (PBS), and 0.02% (w/v) Thimerosal as a preservative.
Concentration	N/A
Conjugation	Unconjugated
Storage Condition	Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below.
Gene Name	hepcidin antimicrobial peptide
Database Link	Entrez Gene 84506 Mouse UniProt ID Q9EQ21
Background	Hepcidin-25 is a 25-residue peptide synthesized in the liver. This is the bioactive form of hepcidin, a key regulator of iron homeostasis. It acts through downregulation of the cellular iron exporter ferroportin, which is expressed on enterocytes, macrophages and hepatocytes. Hepcidin-25 production is upregulated by inflammation as well as iron overload, leading to anemia through interference with the body's intestinal iron absorption and its utilization of iron. Hepcidin is also a small defensin-like peptide with anti-microbial activity, which is secreted into the urine. This antibody was generated by immunization of rabbits with Hepcidin-25 coupled to a carrier protein.
Synonyms	HEPC; HEPCIDIN; HFE2; HFE2B; LEAP-1; LEAP1; PLTR
Reference Data

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