Amylin (IAPP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	This antibody has been tested and validated in ELISA against Amylin and in immunohistochemistry (IHC). Other applications like FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide H-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-NH2 coupled to carrier protein.
Formulation	Protein A affinity purified from antiserum, lyophilized, packaged under nitrogen. Reconstitute by adding 0.4ml distilled water. This stock solution contains 1mg/ml IgG, phosphate buffered saline pH 7.2 (PBS), 6mg/ml bovine serum albumin (BSA) as a stabilizer and 0.05% sodium azide as a preservative.
Concentration	N/A
Conjugation	Unconjugated
Storage Condition	Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated freezing and thawing by freezing aliquots at -20°C or below.
Gene Name	islet amyloid polypeptide
Database Link	Entrez Gene 3375 Human UniProt ID P10997
Background	Amylin (also known as islet amyloid polypeptide, IAPP) in its full length is a 37 amino acid peptide hormone with a disulfide bridge between cysteine residues 2 and 7. Both the amidated C-terminus and the disulfide bridge are necessary for the full biological activity of Amylin. It is co-secreted with insulin from the pancreatic β-cells and plays an important role in the glycemic control, regulating it by slowing gastric emptying and promoting satiety. It is also involved in bone metabolism, along with the related peptides calcitonin and calcitonin gene related peptide, CGRP. This antibody was generated by immunization of rabbits with Amylin (25-37) coupled to a carrier protein.
Synonyms	AMYLIN; DAP; IAP
Reference Data

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