Rnls Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Specificity	Expected reactivity: Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat Homology: Dog: 79%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
Formulation	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. Note that this product is shipped as lyophilized powder to China customers.
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted Protein Size	33kDa
Gene Name	renalase, FAD-dependent amine oxidase
Database Link	NP_001161290 Entrez Gene 55328 HumanEntrez Gene 67795 Mouse UniProt ID A7RDN6
Background	Rnls is a probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. It degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Synonyms	C10orf59; FLJ11218; RENALASE
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.