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TXNIP Rabbit Polyclonal Antibody
CNY 4,628.00
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CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
Specifications
| Product Data | |
| Applications | WB |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | The immunogen is a synthetic peptide directed towards the middle region of human TXNIP |
| Specificity | Expected reactivity: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat Homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93% |
| Formulation | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. Note that this product is shipped as lyophilized powder to China customers. |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage Condition | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Predicted Protein Size | 44kDa |
| Gene Name | thioredoxin interacting protein |
| Database Link | |
| Background | TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells. |
| Synonyms | EST01027; HHCPA78; THIF; VDUP1 |
| Reference Data | |
| Protein Families | Druggable Genome |
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