Ku70 (XRCC6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen is a synthetic peptide directed towards the N terminal region of human G22P1
Specificity	Expected reactivity: Cow, Human Homology: Cow: 79%; Human: 100%
Formulation	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. Note that this product is shipped as lyophilized powder to China customers.
Concentration	lot specific
Purification	Protein A purified
Conjugation	Unconjugated
Storage Condition	For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted Protein Size	70kDa
Gene Name	X-ray repair complementing defective repair in Chinese hamster cells 6
Database Link	NP_001460 Entrez Gene 2547 Human UniProt ID Q6FG89
Background	The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
Synonyms	CTC75; CTCBF; D22S671; D22S731; G22P1; KU70; ML8; OTTHUMP00000199333; OTTHUMP00000199349; TLAA
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Non-homologous end-joining

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