Alkaline Phosphatase (ALPP) Mouse Monoclonal Antibody [Clone ID: 8A9]

Specifications

Product Data
Clone Name	8A9
Applications	IHC
Recommend Dilution	1:50
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified human placental alkaline phosphatase
Specificity	Human placental alkaline phosphatase (PLAP). Immunohistochemical evidence (in house and published) supports reactivity with PLAP and also with PLAP-like enzyme
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	alkaline phosphatase, placental
Database Link	Entrez Gene 250 Human UniProt ID P05187
Background	Placental alkaline phosphatase (PLAP) is a membrane-associated sialoglycoprotein enzyme normally present at high concentration in syncytiotrophoblasts within the placenta during the third trimester of gestation. The expression of PLAP was originally thought to be restricted to term placenta but a human PLAP-like variant has been described which shares more than 85% homology with PLAP itself. This high degree of homology between PLAP and PLAP-like enzyme together with cross-reacting antibodies has led to some confusion of the distribution of PLAP and PLAP-like enzyme in various tissues. PLAP is reported to be expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. PLAP expression is rare in malignant germ cell tumors. PLAP-like enzyme is reported to be predominantly found in normal fetal and neonatal testis, and in thymus. It is also commonly expressed in germ cell tumors and more recently described in seminomas.
Synonyms	ALP; FLJ61142; glycerophosphatase; PALP; PLAP; PLAP-1
Reference Data

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