Mesothelin (MSLN) Mouse Monoclonal Antibody [Clone ID: 5B2]

Specifications

Product Data
Clone Name	5B2
Applications	IHC
Recommend Dilution	1:40
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant prokaryotic fusion protein corresponding to approximately 100 amino acids which are present in the membrane-bound form of the mesothelin molecule.
Specificity	Human mesothelin
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	mesothelin
Database Link	Entrez Gene 10232 Human UniProt ID Q13421
Background	Mesothelin is a glycosyl-phosphatidylinositol-linked (GPI) glycoprotein of 40kD present on the surface of mesothelial cells, mesotheliomas, epithelial ovarian cancers and some squamous cell carcinomas. It is synthesized as a 69 kD precursor which is enzymatically processed into an N-terminal secreted form of 30 kD and the GPI-linked membrane-bound form of 40 kD. The secreted form is identical to the megakaryocyte potentiating factor, but it is the GPI-linked membrane-bound form which has generated interest. Mesothelin is abundantly expressed in the kidney and in occasional epithelial cells of the trachea, tonsil and fallopian tube. The function of mesothelin is unclear but it may have a role in cellular adhesion. Mesothelin is reported to be abundant in the normal mesothelial cells from which malignant mesotheliomas and ovarian cystadenocarcinomas are derived.
Synonyms	CAK1; mesothelin; MPF; SMR
Reference Data

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