Langerin (CD207) Mouse Monoclonal Antibody [Clone ID: 12D6]

Specifications

Product Data
Clone Name	12D6
Applications	IHC
Recommend Dilution	1:50
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein of 29 kD corresponding to the external domain of the langerin molecule
Specificity	Human langerin
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	CD207 molecule
Database Link	Entrez Gene 50489 Human UniProt ID Q9UJ71
Background	Langerin is a type II transmembrane C-type lectin which has mannose-binding specificity. It is a 40 kD protein restricted to Langerhans cells that is involved in the internalization of cell surface material in these immature dendritic cells. Dendritic cells are antigen-presenting cells that are required for initiation of a specific T cell-driven immune response. These cells are found in non-lymphoid tissue as immature cells whose primary function is to capture antigen through specialized surface membrane endocytic structures or through macropinocytosis. The dendritic cells migrate to secondary lymphoid tissue and mature into efficient antigen presenting cells. A part of the maturation process includes the loss of adhesion receptors such as E-cadherin and the disappearance of Birbeck granules. Although Langerin is reported to be located on the cell surface, it can be rapidly internalized following ligand capture into Birbeck granules. In fact, Langerin is a potent inducer of membrane superimposition and zippering leading to Birbeck granule formation. In reports it has been suggested that the induction of Birbeck granules is a consequence of the antigen-capture function of Langerin allowing passage into these organelles and providing access to a non-classical antigen processing pathway.
Synonyms	CLEC4K; Langerin
Reference Data

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