Granzyme B (GZMB) Mouse Monoclonal Antibody [Clone ID: 11F1]

Specifications

Product Data
Clone Name	11F1
Applications	IHC
Recommend Dilution	1:80
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant prokaryotic fusion protein corresponding to the N-terminus of the mature granzyme B molecule
Specificity	Human granzyme B
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	granzyme B
Database Link	Entrez Gene 3002 Human UniProt ID P10144
Background	Granzymes are neutral serine proteases which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. These CTL and NK cells are heavily involved in the elimination of neoplastic and virally infected cells. Secretory granules containing perforin and granzymes are instrumental in undertaking cytolytic activity. Granzyme B is understood to enter a target cell through a perforin pore-formed channel to induce DNA fragmentation and apoptosis. Granzyme B has also been described in neoplastic CTL and NK cells.
Synonyms	C11; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA-1; CTLA1; CTSGL1; Fragmentin-2; Granzyme-2; GRB; HLP; SECT
Reference Data

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