DNAH2 Mouse Monoclonal Antibody [Clone ID: 13H6]

Specifications

Product Data
Clone Name	13H6
Applications	IHC
Recommend Dilution	1:10 - 1:20
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to a region of the rod domain of the human dystrophin molecule
Specificity	Human dystrophin molecule
Formulation	Lyophilized tissue culture supernatant containing 15 mM sodium azide as a preservative.
Reconstitution Method	The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	dynein, axonemal, heavy polypeptide 2
Background	Duchenne Muscular dystrophy (DMD) is the most common of the muscular dystrophies resulting in progressive muscular wasting and death. Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Abnormalities in protein expression occur in patients with DMD/BMD and dystrophin analysis may be used to distinguish these conditions from other neuromuscular diseases. Severe Duchenne muscular dystrophy is associated with a marked dystrophin deficiency, whereas patients with the milder form of Becker muscular dystrophy show less pronounced abnormalities of protein expression. The immunolabeling patterns for DYS1, DYS2 and DYS3 are similar; however, the use of all three antibodies is recommended to avoid the possibility of occasional false negative results.
Reference Data

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