Actin (ACTA1) Mouse Monoclonal Antibody [Clone ID: SC28]

Specifications

Product Data
Clone Name	SC28
Applications	IHC
Recommend Dilution	1:400
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to 187 amino acids of the human MSA molecule
Specificity	Human muscle specific actin
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	actin, alpha 1, skeletal muscle
Database Link	Entrez Gene 58 Human UniProt ID P68133
Background	Muscle specific actin (MSA) is a highly conserved, ubiquitous protein found in muscle and some non-muscle cells. Actins can be divided into three subsets, alpha actins found in muscle tissue cells, beta and gamma actins found in non-muscle cells and a small subset of gamma actins also found in muscle tissue cells. In normal tissues, expression is found in striated fibers of skeletal muscle, smooth muscle in arteries, veins and pericytes of smaller arteries, muscle in bowel, myometrium of the uterus, prostatic stroma, capsule cells of liver, kidney, lymph node and spleen, the myoepithelial layers of mammary ducts and glands, eccrine sweat glands and salivary glands. Expression is not found in epithelial cells, lymphoid cells, macrophages, connective tissue and neuronal cells. In neoplastic tissues, expression can be found in soft tissue tumors with muscle differentiation, for example, leiomyomas, leiomyosarcomas and rhabdomyosarcomas of varying subtypes. Non-muscle sarcomas, carcinomas, melanomas and lymphomas do not express muscle specific actin.
Synonyms	ACTA; Alpha-actin-1; ASMA; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; NEM3
Reference Data

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