Calca Mouse Monoclonal Antibody [Clone ID: CL1948]

Specifications

Product Data
Clone Name	CL1948
Applications	IHC
Recommend Dilution	1:200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant fusion protein containing 32 amino acids corresponding to the mature human calcitonin molecule
Specificity	Human calcitonin
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	calcitonin-related polypeptide alpha
Database Link	UniProt ID P01256
Background	Calcitonin (CT) is a 32 amino acid peptide synthesized by the parafollicular C cells of the thyroid. It acts through its receptors to inhibit osteoclast mediated bone resorption, decrease calcium resorption by the kidney and decrease calcium absorption by the intestines. The action of calcitonin is therefore to cause a reduction in serum calcium, an effect opposite to that of parathyroid hormone. The calcitonin gene transcript also encodes the calcitonin gene-related peptide (CGRP), which is thought to be a potent vasodilator. The tissue specificity of the transcript produced depends on alternative splicing of the CT/CGRP gene transcript. In the parafollicular cells of the thyroid 95% of the CT/CGRP is processed and translated to produce CT, however, in neuronal cells 99% of the CT/CGRP RNA is translated into CGRP. The C cells of the thyroid give rise to an endocrine tumor, medullary thyroid carcinoma (MTC), which occurs in a sporadic (75% of cases) and hereditary form (25% of cases). Familial MTC is associated with C cell hyperplasia (CCH), whereas sporadic MTC is thought not to be. However, in the general population CCH is present in 20-30% of thyroid glands, either with normal histology, thyroiditis or follicular tumors.
Synonyms	CALC1; CGRP; CGRP-I; CGRP1; CT; katacalcin; KC; MGC126648; PCT; Procalcitonin
Reference Data

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