SLAMF7 Rabbit Monoclonal Antibody [Clone ID: DM11]

Specifications

Product Data
Clone Name	DM11
Applications	ELISA, FC, IF, IP
Recommend Dilution	Flow Cyt  1/100
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant human CS1 (Ser23-Met226) (TP723925) produced by using human HEK293 cells
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. Preservative: 0.1% Procline 300
Reconstitution Method	Reconstitute with deionized water
Purification	Purified from cell culture supernatant by affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Predicted Protein Size	37kDa
Gene Name	SLAM family member 7
Database Link	Entrez Gene 57823 Human UniProt ID Q9NQ25
Background	Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Synonyms	19A; CD319; CRACC; CS1
Reference Data

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