PD L2 (PDCD1LG2) Mouse Monoclonal Antibody [Clone ID: 8C12]

Specifications

Product Data
Clone Name	8C12
Applications	FC, IF, IHC, WB
Recommend Dilution	WB: 0.5-1µg/mL. IHC starting at 2µg/mL.IF start at 20µg/mL.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	PD-L2 antibody was raised against the extracellular domain of human PD-L2.
Formulation	PD-L2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	PD-L2 Antibody is supplied as protein A purified IgG1.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 30 kDa; Observed: 38 kDa
Gene Name	programmed cell death 1 ligand 2
Database Link	NP_079515 Entrez Gene 80380 Human UniProt ID Q9BQ51
Background	PD-L2 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PD-L2 can act to stimulate an immunogenic response through and alternative receptor from PD-1.
Synonyms	B7-DC; B7DC; bA574F11.2; Btdc; CD273; MGC142238; MGC142240; PD-L2; PDCD1L2; PDL2
Note	PD-L2 antibody can be used for detection of PD-L2 by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2 µg/mL. For immunofluorescence start at 20 µg/mL.
Reference Data

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