MON1A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from a portion of the intra domain 190-240aa of human Mon1a protein. This sequence is identical to human, mouse, rat, bovine and chicken.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52 kDa
Gene Name	MON1 homolog A, secretory trafficking associated
Database Link	NP_001135973 Entrez Gene 72825 MouseEntrez Gene 84315 Human UniProt ID Q86VX9
Background	SAND-1 (Mon1a (490 aa) and Mon1b (547aa)) and CCZ-1 (Ccz1) are new factors for the apoptotic cells removal. Impaired apoptotic cell clearance (due to defective recognition, internalization or degradation) results in autoimmune disease. Mon1a and Mon1b, are similarly required for phagosome maturation. Mon1a and Mon1b are required for phagosome maturation. Mona and its partner CCZ-1 form a complex (but not either protein alone) could bind small GTPase Rab7, thus influence Rab7 activation, Mon1a, Mon1b and CCZ-1 are critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses.
Synonyms	SAND1
Reference Data

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