H3FA (HIST1H3A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide containing -QTARKSTGGKA-with phosphorylated serine 10 of human Histone H3.
Formulation	This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	17 kDa
Gene Name	histone cluster 1, H3a
Database Link	NP_003520 Entrez Gene 360198 MouseEntrez Gene 679994 RatEntrez Gene 8350 Human UniProt ID P68431
Background	Histones are basic nuclear proteins that together with DNA make up the nucleosome structure in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). Histone H1 and the N-terminal tail of H3 have key roles in the folding and inter-association of the chromatin fiber. Histone phosphorylation influences transcription, chromoscome condensation, DNA repair and apoptosis. The phosphorylation of Histone H3 at Serine 10 is linked to gene activation, prevents methylation at Lys9 but facilitates acetylation of H3 and H4. pSer10 is also associated with c-fos and c-myc genes.
Synonyms	A; H3; H3FA
Reference Data
Protein Pathways	Systemic lupus erythematosus

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