PCSK9 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from 100aa-300aa of Human PCSK9 protein. This sequence is identical among human, rat, mouse, gorilla, etc.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	74 kDa or 64 kDa
Gene Name	proprotein convertase subtilisin/kexin type 9
Database Link	NP_777596 Entrez Gene 100102 MouseEntrez Gene 298296 RatEntrez Gene 255738 Human UniProt ID Q8NBP7
Background	Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the serine protease family with a critical role in cholesterol metabolism by controlling the levels of low density lipoprotein (LDL) particles that circulate in the bloodstream. Mutation in the PCSK9 gene is associated with autosomal dominant hypercholesterolemia which is characterized by an increase in LDL cholesterol levels. PCSK9 is expressed in various tissues such as liver, kidney, lung, spleen, etc. Human PCSK9 precursor is 692 aa protein with 74kDa molecular weight. Its mature form has molecular weight ranging of 62-66 kDa in the tissues.
Synonyms	FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9
Reference Data
Protein Families	Secreted Protein

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