PTEN Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Dot, WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide surrounding to the epitope -DTSDP-- with phosphorylation sites at Ser385 of PTEN protein from human, mouse and rat origins.
Formulation	This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	58 kDa
Gene Name	phosphatase and tensin homolog
Database Link	NP_000305 Entrez Gene 19211 MouseEntrez Gene 50557 RatEntrez Gene 5728 Human UniProt ID P60484
Background	The phosphatase and tensin homologue (PTEN) tumor suppressor is a phosphatidylinositol D3-phosphatase that is frequently mutated in tumor cells. PTEN is itself regulated by phosphorylation on multiple serine and threonine residues in its C terminus. Casein kinase 2 (CK2) and Glycogen synthase kinase 3beta (GSK3beta), ATK/PI3K are involved in PTEN phosphorylation at sites of S370, S380, T382, T383, S385. The PTEN phosphorylation may play critical roles in the tumor suppressor functions.
Synonyms	10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Reference Data
Protein Families	Druggable Genome, Phosphatase
Protein Pathways	Endometrial cancer, Focal adhesion, Glioma, Inositol phosphate metabolism, Melanoma, p53 signaling pathway, Pathways in cancer, Phosphatidylinositol signaling system, Prostate cancer, Small cell lung cancer, Tight junction

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.