Tenascin C (TNC) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Mouse, Rat, Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the internal segment of Tenascin C protein. This sequence is identical among human, rat and mouse.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~240 kDa
Gene Name	tenascin C
Database Link	NP_002151 Entrez Gene 21923 MouseEntrez Gene 116640 RatEntrez Gene 3371 Human UniProt ID P24821
Background	Tenascin-C (TN-C) is an extracellular matrix glycoprotein expressed during embryonic development, as well as in wound healing and cancer invasion in various tissues. It is usually derived from myofibroblasts in the cancer microenvironment. It has diverse functions, including weakening of cell adhesion, up-regulating the expression and activity of matrix metalloproteinases, modulating inflammatory responses, promoting recruitment of myofibroblasts, and enhancing fibrosis. TN-C could exert both harmful and protective effects and might be a therapeutic target as a key molecule in the control of the balance of beneficial and undesirable cellular responses during tissue remodeling. Cancer cell-specific TNC is a novel indicator of poor prognosis.
Synonyms	150-225; DFNA56; GMEM; GP; HXB; JI; TN; TN-C
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways	ECM-receptor interaction, Focal adhesion

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