Aggrecan (ACAN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the 380-400 aa of human ACAN protein. This sequence is identical to bovine, mouse and rat.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	>200 kDa
Gene Name	aggrecan
Database Link	NP_001126 Entrez Gene 11595 MouseEntrez Gene 58968 RatEntrez Gene 176 Human UniProt ID P16112
Background	Aggrecan or aggregating chondroitin sulfate proteoglycan, is an integral part of the extracellular matrix in cartilagenous tissue. Many individual monomers of aggrecan bind to hyaluronic acid to form an aggregate, the monomer is known as aggrecan. The aggregates are comprised of up to 100 monomers attached to a single chain of hyaluronic acid. The high content of negatively charged polysaccharide chains contributes to the osmotic swelling of cartilage and in combination with intact collagen fibers results in articular cartilage resistance to compressive forces and high tensile strength. Aggrecan is abundant in articular cartilage and compromises 10% of its dry weight. The cleavage of Aggrecan has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration.
Synonyms	AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK
Reference Data

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