MTA2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the C-terminus of human p38 protein
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	75 kDa
Gene Name	metastasis associated 1 family member 2
Database Link	NP_004730 Entrez Gene 23942 MouseEntrez Gene 361724 RatEntrez Gene 9219 Human UniProt ID O94776
Background	The mitogen-activated protein kinases (MAPK), also known as extracellular signal-related kinase (ERKs), are praline-directed protein kinases that mediate the effects of numerous extracellular stimuli on a wide array of biological processes, such as cellular proliferation, differentiation and death. There are three groups of mammalian MAP kinases including the ERK, JNK, and p38 MAP kinases. The MAPKs family is also characterized by their requirement for dual phosphorylation at a converved threonine and tyrosine residue for enzymatic activation and both must be phosphorylated for full enzymatic activation. The closely related ERK2 (44kDa) and ERK2 (42kDa) kinases are characterized by their requirement for dual phosphorylation at a converved T-E-Y motif. While JNK1 is activated by dual phosphorylation at a T-P-Y motif and p38 is also activated by dual phosphorylation at a T-G-Y motif.
Synonyms	MTA1L1; PID
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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