CREB1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Dot, WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the epitope of RPSYR with a single phosphorylation site Ser133.
Formulation	This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	40 kDa
Gene Name	cAMP responsive element binding protein 1
Database Link	NP_004370 Entrez Gene 1385 Human UniProt ID P16220
Background	CREB is a bZIP transcription factor that binds the cAMP response element (CRE) and activates target genes. It is involved in many extracellular signals resulting in regulation of a variety of cellular responses. Phosphorylation of CREB at Ser133 by various kinases, such as PKA, PKC, CaM kinase II and IV, is necessary for CREB signaling.
Synonyms	CREB
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Antigen processing and presentation, Huntington's disease, Melanogenesis, Prostate cancer

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