Telomerase reverse transcriptase (TERT) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, IP
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the C-term of TERT protein. This sequence is identical to human, mouse and rat.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~127 kDa
Gene Name	telomerase reverse transcriptase
Database Link	NP_937983 Entrez Gene 7015 Human UniProt ID O14746
Background	Telomeres are specialized structures at the ends of eukaryotic chromosomes which appear to function in chromosome stabilization, positioning and replication. At each cell division, the length of telomeric TTAGGG DNA repeats is shortened and cells ultimately stop dividing. Telomerase is a reverse transcriptase that synthesizes telomere DNA thereby compensating for telomere loss. There are three major components of telomerase, i.e., human telomerase RNA (hTERC), telomerase-associated protein (TEP1), and the human telomerase reverse transcriptase (hTERT), Telomerease is expressed at high levels in the nucleus of proliferating cells, lymphocytes, primary tumors and cancer cell lines.
Synonyms	CMM9; DKCA2; DKCB4; EST2; hEST2; hTRT; PFBMFT1; TCS1; TP2; TRT
Reference Data
Protein Families	Druggable Genome

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