MTA2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the epitope -EDR-S-KSAP- with a phosphorylated Ser 345 of human PKC.
Formulation	This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~90 kDa
Gene Name	metastasis associated 1 family member 2
Database Link	NP_001317221 Entrez Gene 23942 MouseEntrez Gene 361724 RatEntrez Gene 9219 Human UniProt ID O94776
Background	Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. With cytotoxic dose (100 uM) of anticancer drug, cisdiamminedlchloroplatinum(ll) (CDDP) incubation, the phosphorylation and translocation into nuclear of PKC in cancer cells including SKBR-3 which express different PKC isoforms was found. Overexpression of PKC was reported in several hemopoietic cell lines and tumors. PKC-epsilon was considered as a full oncogenic potential.
Synonyms	MTA1L1; PID
Reference Data
Protein Families	Druggable Genome, Transcription Factors

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.