c Abl (ABL1) Mouse Monoclonal Antibody [Clone ID: SPM328]

Specifications

Product Data
Clone Name	SPM328
Applications	IHC, WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	The synthetic peptide corresponding to SH2 domain of c-Abl protein.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~120 kDa
Gene Name	ABL proto-oncogene 1, non-receptor tyrosine kinase
Database Link	NP_005148 Entrez Gene 11350 MouseEntrez Gene 25 Human UniProt ID P00519
Background	The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. It is activated by certain DNA-damaging agents and regulates induction of the stress-activated c-Jun N-terminal protein kinase (SAPK). In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
Synonyms	ABL; abl; bcr; c-ABL; c-ABL1; JTK7; p150; v-abl
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transcription Factors
Protein Pathways	Axon guidance, Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Viral myocarditis

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