Estrogen Receptor beta (ESR2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the c-terminus of human Estrogen Receptor Beta. .
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	53 kDa
Gene Name	estrogen receptor 2
Database Link	NP_001035365 Entrez Gene 2100 Human UniProt ID Q92731
Background	ER (estrogen receptor) belongs to a member of the steroid receptor superfamily. It contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). The transcriptional effects of 17b-estradiol (E2) in the body are mediated by two distinct ERs, ER-alpha and ER-beta. ER-alpha plays an important role in differentiation by regulating target genes such as that for the progesterone receptor (PR). Both the stroma and epithelium express PR, and estrogen induces PR in the stromal and glandular epithelial cells. ER-alpha and ER-beta may have opposite effects on gene transcription. ER-beta can act as a transdominant repressor on ER-alpha transcriptional activity. ER-beta acts as a modulator of ER-alpha-mediated gene transcription in the uterus, and furthermore, that it is responsible for down regulation of PR in the luminal epithelium.
Synonyms	ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2
Reference Data
Protein Families	Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

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