Claudin 7 (CLDN7) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 0.5-2 µg/ml FC Not tested
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	peptide from C-terminus of human claudin 7 protein. This sequence is identical to human, rat, mouse and bovine.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	24 kDa
Gene Name	claudin 7
Database Link	NP_001171951 Entrez Gene 53624 MouseEntrez Gene 65132 RatEntrez Gene 1366 Human UniProt ID O95471
Background	The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudins, which consist of four trans-membrane domains and two extracellular loops, make up tight junction strands. Claudin 7 (CLDN7) has two isoforms, a full-length form with 211 aa residues and a C-terminal truncated form with 158 aa residues. This protein is localized in the intercellular junctions of the epithelial cells of the proximal tubules of the nephrons in mammalian kidney. It is expressed in normal human and mouse epithelia.
Synonyms	CEPTRL2; claudin-1; CLDN-7; CPETRL2; Hs.84359
Reference Data
Protein Families	Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

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