Amylin (IAPP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from N-term of human Amylin peptide.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	10 kDa
Gene Name	islet amyloid polypeptide
Database Link	NP_000406 Entrez Gene 3375 Human UniProt ID P10997
Background	Amylin is a 37 amino acid peptide co-secreted with insulin from pancreatic islet beta-cells. Amylin shares structural similarities with calcitonin gene-related peptide (CGRP) and calcitonin (CT), including an N-terminal ring structure linked by a disulfide bridge, and an amidated C-terminus. The function of Amylin is to maintain the gluocose homoeostasis, include lowered insulin secretion, raised hepatic glucose output, stimulation of glycogenolysis and inhibition of glycogen synthesis in liver cells and in skeletal muscle. Amylin peptide is predominantly found in the beta cells of the pancreas and to a lesser extent in the gastrointestinal tract and nervous system. This antibody can be used for staining of amylin in normal and diabetic pancreas and pancreatic carcinoma
Synonyms	DAP; IAP
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Maturity onset diabetes of the young

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