GABA B Receptor 1 (GABBR1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from N-term of human GABA receptor 1 protein. This sequence is identical to human and rat.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	100 kDa
Gene Name	gamma-aminobutyric acid type B receptor subunit 1
Database Link	NP_001461 Entrez Gene 54393 MouseEntrez Gene 81657 RatEntrez Gene 2550 Human UniProt ID Q9UBS5
Background	Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. It acts at GABA receptors to produce fast synaptic inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The overexpression of one particular gene encoding for G-protein-activated inward rectifying potassium type 2 (GIRK2) channel subunit and its coupling to GABA(B) receptors may contribute to a range of mental and functional disabilities
Synonyms	GABABR1; GABBR1-3; GB1; GPRC3A
Reference Data
Protein Families	Druggable Genome, GPCR, Secreted Protein, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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