ALIX (PDCD6IP) Mouse Monoclonal Antibody [Clone ID: 3A9]

Specifications

Product Data
Clone Name	3A9
Applications	WB
Recommend Dilution	WB, IP, IF
Reactivity	Human, Mouse, Frog
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant full-length human Alix protein
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	95.8 kDa
Gene Name	programmed cell death 6 interacting protein
Database Link	NP_037506 Entrez Gene 18571 MouseEntrez Gene 10015 Human UniProt ID Q8WUM4
Background	Alix (ALG-2-interacting protein X) is an adaptor protein that was first described for its capacity to bind to the calcium-binding protein ALG-2, the expression of which seemed necessary for cell death. The predicted molecular weight is approximately 96 kD. Alix contains an N-terminal Bro1 domain and a C-terminal proline-rich domain (PRD). The PRD contains multiple polyproline motifs, which are potential docking sites for proteins containing SH3 domains, interact with multiple cellular Alix-binding partners that are involved in apoptotic induction, endosomal sorting, and endocytosis. The Bro1 domain interacts with CHMP4b, which is also involved in endosomal sorting.
Synonyms	AIP1; ALIX; DRIP4; HP95
Note	Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 1 µg/ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Endocytosis

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