Tryptophan 5 hydroxylase 2 (TPH2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Huvec cells IHC: 10-50 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm and Cell membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human TPH2
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	56 kDa
Gene Name	tryptophan hydroxylase 2
Database Link	NP_775489 Entrez Gene 216343 MouseEntrez Gene 317675 RatEntrez Gene 121278 Human UniProt ID Q8IWU9
Background	This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem.
Synonyms	ADHD7; NTPH
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Tryptophan metabolism

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