Renalase (RNLS) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: K562 cell, Human cerebella tissue lysates IHC: 50-200 Positive control: Human breast cancer Predicted cell location: Secreted
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human RNLS
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	38 kDa
Gene Name	renalase, FAD-dependent amine oxidase
Database Link	NP_001026879 Entrez Gene 67795 MouseEntrez Gene 361751 RatEntrez Gene 55328 Human UniProt ID Q5VYX0
Background	Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney. Catalyzes the oxidation of the less abundant alpha-NAD(P)H isoform toform beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk.
Synonyms	C10orf59; RENALASE
Reference Data
Protein Families	Secreted Protein

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