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CAB39 Rabbit Polyclonal Antibody
CAT＃: TA351407S
Rabbit Polyclonal Anti-CAB39 Antibody
Size: 100 ul
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CN¥ 800.00
CN¥ 1,280.00
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CN¥ 2,900.00
CN¥ 6,650.00
CN¥ 3,080.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 500-2000 WB positive control: 293T and LoVo cells, human brain malignant glioma tissue IHC: 50-200 Positive control: Human cervical cancer Predicted cell location: Cytoplasm and Nucleus |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human CAB39 |
| Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 40 kDa |
| Gene Name | calcium binding protein 39 |
| Database Link | |
| Background | Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK). |
| Synonyms | CGI-66; MO25 |
| Reference Data | |
| Protein Pathways | mTOR signaling pathway |
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