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Seladin 1 (DHCR24) Rabbit Polyclonal Antibody
CAT＃: TA350394S
Rabbit Polyclonal Anti-DHCR24 rabbit polyclonal antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 200-1000 WB positive control: Jurkat and HepG2 cells IHC: 30-150 Positive control: Human breast cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human DHCR24 |
| Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 60 kDa |
| Gene Name | 24-dehydrocholesterol reductase |
| Database Link | |
| Background | This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. |
| Synonyms | DCE; Nbla03646; seladin-1; SELADIN1 |
| Reference Data | |
| Protein Families | Druggable Genome, Stem cell - Pluripotency, Transmembrane |
| Protein Pathways | Metabolic pathways, Steroid biosynthesis |
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