Phosphoribosyl pyrophosphate amidotransferase (PPAT) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Hela, Raji, Jurkat, A549 and NIH/3T3 cells IHC: 100-300 Positive control: Human cervical cancer Predicted cell location: Cytoplasm and Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human PPAT
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	57 kDa
Gene Name	phosphoribosyl pyrophosphate amidotransferase
Database Link	NP_002694 Entrez Gene 117544 RatEntrez Gene 231327 MouseEntrez Gene 5471 Human UniProt ID Q06203
Background	The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region.
Synonyms	ATASE; GPAT; PRAT
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Alanine, aspartate and glutamate metabolism, Metabolic pathways, Purine metabolism

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