OATP2 (SLCO1B1) Rabbit Polyclonal Antibody
CAT#: TA349179
Rabbit Polyclonal Anti-SLCO1B1 Antibody
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CNY 5,808.00
货期*
5周
规格
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Specifications
Product Data | |
Applications | ELISA, ICC, IF, WB |
Recommend Dilution | SLCO1B1 antibody can be used for detection of SLCO1B1 by Western blot at 1 - 2 µg/ml. For immunofluorescence start at 20 µg/mL. Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | SLCO1B1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human SLCO1B1. |
Specificity | SLCO1B1 antibody is human specific. At least four isoforms of SLCO1B1 are known to exist. This antibody is predicted to not cross-react with other SLCO1B proteins. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | SLCO1B1 antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage Condition | Store at +4°C as received. |
Predicted Protein Size | Predicted: 76 kDa; Observed: 75 kDa |
Gene Name | solute carrier organic anion transporter family member 1B1 |
Database Link | |
Background | SLCO1B1 is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and may play an important role in the clearance of bile acids and organic anions from the liver (1,2). It contains one Kazal-like domain and belongs to the organo-anion transporter family (2,3). SLCO1B1 is highly expressed in liver and is localized to the basolateral hepatocyte membrane. It is responsible for the hepatic uptake of the liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in mouse, rat and human (3,4). |
Synonyms | FAT10; GABBR1; UBD-3 |
Reference Data |
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