WSB1 Rabbit Polyclonal Antibody
CNY 5,808.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 3,080.00
CNY 9,998.00
CNY 3,080.00
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | WSB1 antibody was raised against a 16 amino acid peptide near the amino terminus of human WSB1. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | WSB1 antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | Predicted: 46 kDa; Observed: 46 kDa |
Gene Name | WD repeat and SOCS box containing 1 |
Database Link | |
Background | The WD repeat and SOCS box-containing 1 (WSB1, also known as SWIP1), is a member of the WD-protein subfamily (1). It contains six WD-repeats spanning most of the protein and an SOCS box in the C-terminus and expressed as multiple alternatively spliced isoforms (1,2). WSB1 is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as DIO2 (3). Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis (4,5). |
Synonyms | SWIP1; WSB-1 |
Reference Data | |
Protein Families | Druggable Genome |
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