ATG4A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ATG4A antibody was raised against an 18 amino acid peptide near the carboxy terminus of human ATG4A.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	ATG4A antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 48 kDa; Observed: 44 kDa
Gene Name	autophagy related 4A cysteine peptidase
Database Link	NP_443168 Entrez Gene 666468 MouseEntrez Gene 678769 RatEntrez Gene 100910507 RatEntrez Gene 115201 Human UniProt ID Q8WYN0
Background	Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). ATG4A, also known as AUTL2, is one of four mammalian orthologs of the yeast ATG4 protein; all four are cysteine proteases (3). ATG4 is required for ATG8 conjugation to phosphatidylethanolamine on autophagosomal membranes. In mammals, each ATG4 homolog shows a selective preference for the ATG8 homologs (4).
Synonyms	APG4A; AUTL2
Reference Data
Protein Families	Protease
Protein Pathways	Regulation of autophagy

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