HES5 Rabbit Polyclonal Antibody

CAT#: TA349126

Rabbit Polyclonal Anti-HES5 Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

Product images

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Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen HES5 antibody was raised against a 19 amino acid peptide near the amino terminus of human HES5.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification HES5 antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size Predicted: 18 kDa; Observed: 17 kDa
Gene Name hes family bHLH transcription factor 5
Background HES5 is a member of the HES family of transcriptional repressors, which are the mammalian homologs of the Drosophila Hairy and Enhancer of Split and contain basic Helix-loop-helix (bHLH) and Orange domains (1). The HES5 gene is a downstream target of the Notch signaling pathway and its expression is downregulated during human cartilage differentiation (2). HES5 can directly repress transcription of the E3 ligase FBW7-beta, creating a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions (3).
Synonyms bHLHb38
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways Notch signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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