alpha Synuclein (SNCA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	SNCA antibody was raised against a 19 amino acid peptide near the carboxy terminus of human SNCA.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	SNCA antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 12 kDa; Observed: 16 kDa
Gene Name	synuclein alpha
Database Link	NP_000336 Entrez Gene 6622 Human UniProt ID P37840
Background	Alpha-Synuclein (SNCA) is a hallmark of Alzheimer?? disease (1,2). It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2). SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3). Defects in SNCA are associated with familial Parkinson?? disease (4,5).
Synonyms	BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16; RTPS2; SNF2; SNF2L4; SNF2LB; SWI2
Reference Data

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