Corticotropin Releasing Factor (CRH) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	CRH antibody was raised against a 16 amino acid peptide near the amino terminus of human CRH.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	CRH antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 22 kDa; Observed: 29 kDa
Gene Name	corticotropin releasing hormone
Database Link	NP_000747 Entrez Gene 1392 Human UniProt ID P06850
Background	Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1). In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2). Marked reduction in this protein has been observed in association with Alzheimer disease (3).
Synonyms	CRF; CRH1
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Long-term depression

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