OLIG1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	OLIG1 antibody was raised against an 18 amino acid peptide near the amino terminus of human OLIG1.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	OLIG1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 30 kDa; Observed: 29 kDa
Gene Name	oligodendrocyte transcription factor 1
Database Link	NP_620450 Entrez Gene 116448 Human UniProt ID Q8TAK6
Background	The oligodendrocyte transcription factors 1 and 2 (OLIG1 and OLIG2, respectively) make up part of basic helix-loop-helix (bHLH) family of transcription factors that are specifically expressed in zones of the neuroepithelium from which oligodendrocyte precursors emerge (1). Both OLIG1 and OLIG2 genes are downstream targets of Sonic hedgehog and are expressed exclusively in the central nervous system (2). OLIG1 is first expressed in the dorsal portion of the p3 progenitor domain of the ventral neural tube while OLIG2 is first observed in the ventral most p3 domain (2). OLIG1 has been shown to be a SMAD cofactor involved in cell motility induced by transforming growth factor-beta (TGF-beta) (3).
Synonyms	BHLHB6; BHLHE21
Reference Data
Protein Families	Druggable Genome

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