TRF2 (TERF2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	TERF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TERF2.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	TERF2 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 60 kDa; Observed: 69 kDa
Gene Name	telomeric repeat binding factor 2
Database Link	NP_005643 Entrez Gene 7014 Human UniProt ID Q15554
Background	The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1). TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2). TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3). TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5).
Synonyms	AD-004; CGI-137; CINAP; CIP; hCINAP
Reference Data

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