CFTR Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CFTR antibody was raised against an 18 amino acid peptide near the carboxy terminus of human CFTR.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	CFTR antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 163 kDa; Observed: 160 kDa
Gene Name	cystic fibrosis transmembrane conductance regulator
Database Link	NP_000483 Entrez Gene 12638 MouseEntrez Gene 24255 RatEntrez Gene 1080 Human UniProt ID P13569
Background	The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a member of the ATP-binding cassette (ABC) transporter superfamily, and a member of the MRP subfamily that is involved in multi-drug resistance (1,2). CFTR functions as a chloride channel and controls the regulation of other transport pathways (3). Mutations in this gene are associated with the autosomal recessive disorder cystic fibrosis, the most common, fatal, inherited disease of caucasian populations (1).
Synonyms	ABC35; ABCC7; CF; CFTR; dJ760C5.1; MRP; MRP7; TNR-CFTR
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	ABC transporters, Vibrio cholerae infection

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