Vinculin (VCL) Mouse Monoclonal Antibody [Clone ID: 7E10]

Specifications

Product Data
Clone Name	7E10
Applications	WB
Recommend Dilution	WB: 0.5 - 1 ug/mL
Reactivity	Human, Mouse, Rat, Rabbit, Chicken
Host	Mouse
Clonality	Monoclonal
Immunogen	Vinculin antibody was raised against a 23 amino acid peptide near the amino terminus of human Vinculin.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Vinculin antibody is purified via Protein A prification.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 117 kDa; Observed: 120 kDa
Gene Name	vinculin
Database Link	NP_003364 Entrez Gene 22330 MouseEntrez Gene 305679 RatEntrez Gene 7414 Human UniProt ID P18206
Background	Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1). Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2). Expression of vinculin were shown to be affected by the level of actin expression (2,3). Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4). Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5).
Synonyms	CMD1W; CMH15; HEL114; MV; MVCL
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adherens junction, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton

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