ROR1 Goat Polyclonal Antibody

Specifications

Product Data
Applications	IHC, PEP-ELISA
Recommend Dilution	IHC: 3-6 ug/ml
Reactivity	Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	The immunogen for Anti-ROR1 Antibody: Peptide with sequence C-GNKSQKPYKIDSKQA, from the C-Terminus (near) of the protein sequence according to NP_005003.2.
Formulation	Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	receptor tyrosine kinase-like orphan receptor 1
Database Link	NP_005003 Entrez Gene 26563 MouseEntrez Gene 362550 RatEntrez Gene 4919 Human UniProt ID Q01973
Background	This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Synonyms	dJ537F10.1; NTRKR1
Note	This antibody is expected to recognize isoform 1 (NP_005003.2) only.
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane

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