GAB2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat
Modifications	Phospho-specific
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Phospho-Gab2(Tyr452) Antibody: A synthesized peptide derived from human Gab2 around the phosphorylation site of Tyrosine 452
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	75 kDa
Gene Name	GRB2 associated binding protein 2
Database Link	NP_536739 Entrez Gene 14389 MouseEntrez Gene 84477 RatEntrez Gene 9846 Human UniProt ID Q9UQC2
Background	This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Synonyms	KIAA0571
Note	Phospho-Gab2(Tyr452) Antibody detects endogenous levels of Gab2 only when phosphorylated at Tyrosine 452
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Chronic myeloid leukemia, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis

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